HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → (S)-3-(2-fluoropyridin-4-yl)-1-methoxy-7-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | 2-Fluoropyridine-4-boronic acid | HCID 2783396 | — |
| Reactant | (S)-7-bromo-3-chloro-1-methoxy-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine | HCID 58466132 | — |
| Product | (S)-3-(2-fluoropyridin-4-yl)-1-methoxy-7-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine | HCID 53465209 | — |
Reaction Steps
The titled compound was synthesized by steps analogous to those described in method AA1 above, but using (S)-7-bromo-3-chloro-1-methoxy-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared as described in Method CC16), pyridin-3-ylboronic acid and 2-fluoropyridin-4-ylboronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-a796cdfb7e3c48efa56ff203f652733c |
| Source note | uspto-grants-2014_11 |