HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → (S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(pyridin-3-yl)-5H-spiro[thiazole-4,9'-xanthen]-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 2734656 | — |
| Reactant | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Reactant | (S)-2-amino-7'-bromo-4'-fluoro-5H-spiro[thiazole-4,9'-xanthen]-2'-ol | HCID 67383112 | — |
| Product | (S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(pyridin-3-yl)-5H-spiro[thiazole-4,9'-xanthen]-2-amine | HCID 53464382 | — |
Reaction Steps
The titled compound was synthesized by stpes analogous to those described in method AA8 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[thiazole-4,9′-xanthen]-2′-ol (prepared as described in Method BB26 and Example 2 but using 7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one), 2-fluoropyridin-3-ylboronic acid and 3-pyridineboronic acid pinacol ester. MS m/z=459.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-70019c2c3a7e4128836f69df2512c2e4 |
| Source note | uspto-grants-2014_11 |