2-Fluoropyridine-3-boronic acid → (S)-2'-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-5H-spiro[thiazole-4,9'-xanthen]-2-amine

Participants

Reaction Steps

The titled compound was synthesized by stpes analogous to those described in method AA20 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[thiazole-4,9′-xanthen]-2′-ol (prepared as described in Method BB26 and Example 2 but using 7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one), 2-fluoropyridin-3-ylboronic acid and 2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride. MS m/z=479.0 [M+H]+.

Provenance & Evidence