HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate | HCID 86655593 | — |
Reaction Steps
To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08884030B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-1804e11b29564a76b2ae02d64aedaf3a |
| Source note | uspto-grants-2014_11 |