Potassium Hydroxide → 22-(Nonafluorobutyl)-1-docosanol

Participants

Reaction Steps

In a similar manner to the synthesis of C4F9(CH2)17OH above, C4F9CH2CHI(CH2)20OH was treated with zinc in glacial acetic acid to afford a mixture of the reduction product alcohols and acetates as well as their corresponding olefins. The mixture was treated essentially as described above with potassium hydroxide to hydrolyze the acetate esters and finally treated with hydrogen to remove the olefinic impurities and recrystallized from hexane. Approximately 16.8 g of white solids C4F9(CH2)22OH was obtained from this process with 98% purity as confirmed by GC/MS.

Provenance & Evidence