Ethylenediamine → HCID 12342949, compound

HRID 336070Notes

Reaction equation

HRID 336070 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.[CH2:19]([NH2:22])[CH2:20][NH2:21]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:22][CH2:19][CH2:20][N:21]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 1230724,4'-Difluorobenzil

Product 1

HCID 12342949HCID 12342949, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
105 °C

Procedure

First, with dehydrated ethanol as a solvent, 16.8 g of 4,4′-difluorobenzil (by Tokyo Chemical Industry Co., Ltd.) and 4.5 g of ethylenediamine (by Kanto Chemical Co., Inc.) were mixed, and the mixture was refluxed at 105° C. for six hours. After reaction, a reaction solution was condensed by using an evaporator, and an obtained residue was recrystallized by using ethanol; thus, 2,3-bis(4-fluorophenyl)-5,6-dihydropyrazine was obtained (reddish brown powder, yield: 93%).

Workup

  1. customAfter reaction
  2. customcondensed
  3. customan evaporator
  4. customan obtained residue was recrystallized

Sources & evidence

ORD record
ord-5b95d9154a5644eea1e5aba8b5bc9550
Source dataset
uspto-grants-2014_11
Patent number
US08889266B2

Reaction notes

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