Methyl iodide → HCID 66683883, compound

Participants

Reaction Steps

To a solution of 5-(benzofuran-2-yl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone (1.11 g) in methanol (10 ml) is added potassium carbonate (476 mg), followed by methyl iodide (214 μl) and the resulting suspension heated to reflux for 17 hours. The crude reaction mixture is then concentrated in vacuuo and partitioned between ethyl acetate (50 ml) and water (50 ml) and the organic layer purified by automated flash chromatography to give 5-[1-benzofuran-2-yl-meth-(E)-ylidene]-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone (337 mg).

Provenance & Evidence