反应详情

To a solution of 4-[1-(3-methylthiophen-2-yl)-meth-(E)-ylidene]-2-(2,4,6-trimethylphenyl)cyclopentane-1,3-dione (100 mg, 0.31 mmol) in methanol (10 ml) is hydrogenated in a H-Cube using 10% palladium on charcoal at 40° C. and 10 bar hydrogen pressure with a flow rate of 0.5 ml/min. The eluate collected is concentrated under vacuum to give a residue which is purified by silica gel column chromatography to give 4-(3-methylthiophen-2-ylmethyl)-2-(2,4,6-trimethylphenyl)cyclopentane-1,3-dione.

1. customat 40° C.
2. customThe eluate collected
3. concentrationis concentrated under vacuum
4. customto give a residue which
5. customis purified by silica gel column chromatography