4-Nitrobenzenesulfonyl chloride → HCID 54767381, compound

Participants

Reaction Steps

2-Hydroxypyridine-1-oxide (0.5 g, 4.5 mmol) was reacted with 4-nitrobenzenesulfonyl chloride (3.0 g, 13.5 mmol) in 40 mL of pyridine to afford PZBG-1c in 92% yield (1.23 g, 4.2 mmol). 1H NMR (500 MHz, CDCl3) δ=8.42 (d, J=8.6 Hz, 2H), 8.23 (d, J=9.2 Hz, 2H), 7.65 (dd, J1=7.5 Hz, J2=1.8 Hz, 1H), 7.34 (dt, J1=9.2 Hz, J2=1.7 Hz, 1H), 6.52 (d, J=9.2 Hz, 1H), 6.22 (t, J=7.7 Hz, 1H). 13C NMR (100 MHz, DMSO) δ=156.6, 152.3, 141.6, 139.4, 138.3, 131.8, 125.6, 122.8, 106.4. ESI-MS(+): m/z 297.28 [M+H]+, 319.02 [M+Na]+.

Provenance & Evidence