Deferiprone → HCID 86660355, compound

Participants

Reaction Steps

3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (0.2 g, 1.4 mmol) was reacted with p-toluenesulfonyl chloride (0.82 g, 4.3 mmol) in 10 mL of pyridine to afford PZBG-3b in 86% yield (0.35 g, 1.2 mmol). 1H NMR (500 MHz, CDCl3) δ=7.99 (d, J=8.4 Hz, 2H), 7.40 (d, J=7.6 Hz, 1H), 7.33 (d, J=8 Hz, 2H), 6.40 (d, J=7.2 Hz, 1H), 3.64 (s, 3H), 2.42 (s, 3H), 2.41 (s, 3H). 13C NMR (100 MHz, CDCl3) δ=170.71, 145.67, 145.54, 141.48, 134.07, 129.72, 128.96, 126.07, 117.53, 42.25, 22.00, 14.7. ESI-MS(+): m/z 294.05 [M+H]+, 315.97 [M+Na]+.

Provenance & Evidence