反应详情

3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (0.2 g, 1.5 mmol) was reacted with 4-nitrobenzenesulfonyl chloride (0.488 g, 2.2 mmol) in 10 mL of pyridine to afford PZBG-3c in 50% yield (0.23 g, 0.7 mmol). 1H NMR (400 MHz, CDCl3) δ=8.41-8.34 (m, 4H), 7.26 (d, J=7.6 Hz, 1H), 6.33 (d, J=7.6 Hz, 1H), 3.67 (s, 3H), 2.53 (s, 3H). 13C NMR (100 MHz, CDCl3) 6=170.9, 150.9, 144.9, 143.2, 140.9, 140.1, 130.4, 124.0, 118.4, 41.9, 14.6. ESI-MS(+): m/z 325.11 [M+H]+, 346.96 [M+Na]+.

1. customto afford PZBG-3c in 50% yield (0.23 g, 0.7 mmol)