Deferiprone → HCID 54767212, compound

Participants

Reaction Steps

The synthesis of B12 was accomplished following the procedure outlined for B1 using 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (80 mg, 0.54 mmol), 4-bromomethylphenyl boronic acid pinacol ester (180 mg, 0.59 mmol), and K2CO3(223 mg, 1.6 mmol) in 8 mL of acetonitrile affording B12 in 50% yield (0.09 g, 0.26 mmol). 1HNMR (400 MHz, CDCl3) δ=7.70 (d, J=8.4 Hz, 2H), 7.36 (d, J=8.4 Hz, 2H), 7.11 (d, J=7.6 Hz, 1H), 6.27 (d, J=7.6 Hz, 1H), 5.18 (s, 2H), 3.44 (s, 3H), 2.02 (s, 3H), 1.29 (s, 12H). 13C NMR (100 MHz, CDCl3) δ=173.55, 146.13, 141.63, 140.83, 139.19, 134.91, 128.46, 117.21, 84.05, 73.00, 41.80, 24.97, 13.15. ESI-MS(+): m/z 356.20 [M+H]+, 378.10 [M+Na]+.

Provenance & Evidence