反应详情

温度

215 °C

2.1]octane-2,4-dione (LXVI). Ethyl 1-benzyl-5-(benzylcarbamoyl)pyrrolidine-2-carboxylate (LXV, 0.00122 mol, 450 mg) was heated under stirring at 210-220° C. for 3 h under atmospheric pressure and the formed ethyl alcohol was collected. After completion of the reaction (checked by TLC), the reaction mixture was cooled at room temperature and the residue was purified by column chromatography (silica gel, 60-120 mesh; EA-Hexane, 2:8) to afford the 3,8-dibenzyl-3,8-diazabicyclo[3.2.1]octane-2,4-dione in 40-45% yield.

1. customthe formed ethyl alcohol was collected
2. customAfter completion of the reaction (checked by TLC)
3. temperaturethe reaction mixture was cooled at room temperature
4. customthe residue was purified by column chromatography (silica gel, 60-120 mesh; EA-Hexane, 2:8)