Sodium Hydroxide → 4-(4-Methyl-3-thienyl)-3-(trifluoromethyl)benzoic acid

HRID 336249Notes

Reaction equation

[OH-].[Na+].[CH3:3][C:4]1[C:5]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][C:10]=2[C:19]([F:22])([F:21])[F:20])=[CH:6][S:7][CH:8]=1>CCO>[CH3:3][C:4]1[C:5]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]=2[C:19]([F:22])([F:20])[F:21])=[CH:6][S:7][CH:8]=1

Participants

Conditions

Temperature: 60 °C

Procedure

Sodium hydroxide (5M: 6 mL; 30 mmol; 3 eq.) was added to a solution of methyl 4-(4-methyl-3-thienyl)-3-(trifluoromethyl)benzoate (3 g; 10 mmol; 1 eq.) in EtOH (90 mL) and the reaction mixture was stirred at 60° C. for 2 hours. After evaporation of the solvent, the residue was taken up in water (300 mL) and the aqueous phase was washed with ethyl acetate (2×100 mL) then acidified to pH 2 with conc. HCl. The solution was concentrated to ca. 100 mL and extracted with ethyl acetate. The organic layer was dried over magnesium sulphate and concentrated in vacuo to afford the title compound (2.6 g, 91%) as a brown oil.

Workup

customAfter evaporation of the solvent
washthe aqueous phase was washed with ethyl acetate (2×100 mL)
concentrationThe solution was concentrated to ca. 100 mL
extractionextracted with ethyl acetate
dry with materialThe organic layer was dried over magnesium sulphate
concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-ec903cf1e8b943cea6e09dada25ae2ff
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889668B2

Reaction notes

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