HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 336260Generated: October 30, 2026
2-Methylpiperidine → 5-Methyl-6-(2-methylpiperidin-1-yl)nicotinonitrile
https://huagongshe.com/reaction/336260
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylpiperidine | HCID 7974 | — |
| Reactant | 5-Cyano-2-fluoro-3-picoline | HCID 23288269 | — |
| Product | 5-Methyl-6-(2-methylpiperidin-1-yl)nicotinonitrile | HCID 67400585 | — |
Reaction Steps
A mixture of 5-cyano-2-fluoro-3-methylpyridine (Molekula M52391889; 1.5 g; 11 mmol; 1 eq.) and 2-methylpiperidine (5.2 mL; 44.1 mmol; 4 eq.) was stirred at 90° C. for 16 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08889668B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-8761c349e3134a7f85bf3a9876c2e5e3 |
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| Source note | uspto-grants-2014_11 |
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