HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-(2',4'-Dimethoxy-2-methylbiphenyl-4-YL)-3-(2-methoxyphenyl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-Hydroxy-2-methoxy-benzamidine | HCID 4652214 | — |
| Reactant | 4-(2,4-Dimethoxyphenyl)-3-methylbenzoic acid | HCID 53227204 | — |
| Product | 5-(2',4'-Dimethoxy-2-methylbiphenyl-4-YL)-3-(2-methoxyphenyl)-1,2,4-oxadiazole | HCID 25256567 | — |
Reaction Steps
Oxalyl chloride (112 μL; 1.32 mmol; 3 eq.), Intermediate 28 (120 mg; 0.44 mmol; 1 eq.), Intermediate 1 (73 mg; 0.44 mmol, 1 eq.) and DIEA (228 μL; 1.32 mmol; 3 eq.) were reacted according to general procedure 2. Purification by precipitation from DCM/n-pentane afforded the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-83af8c860b1640daa2fbd59c9749c7ec |
| Source note | uspto-grants-2014_11 |