HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-(2-Methoxy-2'-methylbiphenyl-4-YL)-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide | HCID 2794708 | — |
| Reactant | 3-Methoxy-4-(2-methylphenyl)benzoic acid | HCID 18001076 | — |
| Product | 5-(2-Methoxy-2'-methylbiphenyl-4-YL)-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole | HCID 25256656 | — |
Reaction Steps
Oxalyl chloride (126 μL; 1.49 mmol; 3 eq.), Intermediate 27 (120 mg; 0.5 mmol; 1 eq.), Intermediate 2 (109 mg; 0.5 mmol, 1 eq.) and DIEA (256 μL; 1.5 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography c-hexane/ethyl acetate, 95/5) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-45731e71d3c6467b92b9affbb31144fa |
| Source note | uspto-grants-2014_11 |