HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-[2'-Methyl-2-(trifluoromethyl)biphenyl-4-YL]-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide | HCID 2794708 | — |
| Reactant | 2'-Methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid | HCID 59495813 | — |
| Product | 5-[2'-Methyl-2-(trifluoromethyl)biphenyl-4-YL]-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole | HCID 25256658 | — |
Reaction Steps
Oxalyl chloride (109 μL; 1.28 mmol; 3 eq.), Intermediate 34 (120 mg; 0.43 mmol; 1 eq.), Intermediate 2 (94 mg; 0.43 mmol, 1 eq.) and DIEA (221 μL; 1.28 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography c-hexane/ethyl acetate, 95/5) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-3e5c08702c72430490640dead6339767 |
| Source note | uspto-grants-2014_11 |