HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-(2-Methoxyphenyl)-5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-YL]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-Hydroxy-2-methoxy-benzamidine | HCID 4652214 | — |
| Reactant | 2'-Methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid | HCID 59495813 | — |
| Product | 3-(2-Methoxyphenyl)-5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-YL]-1,2,4-oxadiazole | HCID 25256391 | — |
Reaction Steps
Oxalyl chloride (109 μL; 1.28 mmol; 3 eq.), Intermediate 34 (120 mg; 0.43 mmol; 1 eq.), Intermediate 1 (71 mg; 0.43 mmol, 1 eq.) and DIEA (95 μL; 1.28 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography c-hexane/ethyl acetate, 95/5) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-7a687bfef11942eca58097b6a3bf55ea |
| Source note | uspto-grants-2014_11 |