HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → HCID 25255280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Methyl-4-(1-piperidinyl)benzoic acid | HCID 33780837 | — |
| Reactant | 5-fluoro-N'-hydroxy-2-methoxybenzenecarboximidamide | HCID 72336823 | — |
| Product | HCID 25255280 | HCID 25255280 | — |
Reaction Steps
Oxalyl chloride (139 μL; 1.64 mmol; 3 eq.), Intermediate 33 (120 mg; 0.55 mmol; 1 eq.), Intermediate 23 (101 mg; 0.55 mmol, 1 eq.) and DIEA (283 μL; 1.64 mmol; 3 eq.) were reacted according to general procedure 2. Purification by preparative HPLC (increasing amount of 0.1% TFA in CH3CN, in 0.1% TFA in water) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-48faa27ef3d74b59b78c68c6fbd2bd13 |
| Source note | uspto-grants-2014_11 |