HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-[4-(4-Methyl-3-thienyl)-3-(trifluoromethyl)phenyl]-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide | HCID 2794708 | — |
| Reactant | 4-(4-Methyl-3-thienyl)-3-(trifluoromethyl)benzoic acid | HCID 59495818 | — |
| Product | 5-[4-(4-Methyl-3-thienyl)-3-(trifluoromethyl)phenyl]-3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole | HCID 25255378 | — |
Reaction Steps
Oxalyl chloride (106 μL; 1.26 mmol; 3 eq.), Intermediate 32 (120 mg; 0.42 mmol; 1 eq.), Intermediate 2 (92 mg; 0.42 mmol, 1 eq.) and DIEA (217 μL; 1.26 mmol; 3 eq.) were reacted according to general procedure 2. Purification by crystallisation from MeOH afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889668B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-98e9d83e6f694688a7f9f45e0bc3629f |
| Source note | uspto-grants-2014_11 |