Oxalyl chloride → HCID 25255381, compound

Participants

Role	Name	HCID	Charge
Reactant	Oxalyl chloride	HCID 65578	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	HCID 59606547	HCID 59606547	—
Reactant	5-fluoro-N'-hydroxy-2-methoxybenzenecarboximidamide	HCID 72336823	—
Product	HCID 25255381	HCID 25255381	—

Reaction Steps

Oxalyl chloride (84 mg; 0.66 mmol; 3 eq.), Intermediate 37 (50 mg; 0.22 mmol; 1 eq.), Intermediate 23 (41 mg; 0.22 mmol, 1 eq.) and DIEA (85 mg; 0.66 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography c-hexane/ethyl acetate, 90/10 then 85/15) afforded the title compound as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08889668B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-55b00f1f64b048539737db872c6c0d3c
Source note	uspto-grants-2014_11