Hydrochloric Acid → HCID 178524852, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 6,7-difluoro-3-hydroxyquinoxaline-2-carboxylate (500 mg, 2.0 mmol) and lithium hydroxide monohydrate (330 mg, 7.9 mmol) in THF (10 mL) and water (5 mL) was heated at 50° C. under nitrogen for 1 h. The mixture was further cooled to 0° C., acidified to pH 2 with concentrated HCl and extracted with ethyl acetate (100 mL). The organic extract was washed with brine (50 mL), dried over magnesium sulfate, filtered and the solvents were removed under reduced pressure to provide 6,7-difluoro-3-hydroxyquinoxaline-2-carboxylic acid as a yellow solid: 1H NMR (400 MHz, CD3OD) δ 7.88 (dd, 1H), 7.29 (dd, 1H) ppm; ESI MS m/z 225 [M−H]−.

Provenance & Evidence