Potassium Hydroxide → HCID 178504656, compound

HRID 336355Notes

Reaction equation

HRID 336355 reaction equation
[OH-].[K+].[OH:3][C:4]1[C:5]([C:18]([O:20]CC)=[O:19])=[N:6][C:7]2[C:12]([N:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2>C(O)C.O>[OH:3][C:4]1[C:5]([C:18]([OH:20])=[O:19])=[N:6][C:7]2[C:12]([N:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 178470161HCID 178470161, compound

Product 1

HCID 178504656HCID 178504656, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Potassium hydroxide (1.0 mL, 1.8 mmol, 1.0 N solution) was added to a suspension of ethyl 3-hydroxy-6-(methylsulfonyl)quinoxaline-2-carboxylate (249 mg, 0.84 mmol) in ethanol (30 mL) and the resulting mixture was heated at reflux for 2 h. The cooled mixture was diluted with water (10 mL), acidified to pH 1 and the resulting solids were collected by filtration under reduced pressure to provide 3-hydroxy-6-(methylsulfonyl)quinoxaline-2-carboxylic acid as an off-white solid: 1H NMR (400 MHz, CDCl3) δ 8.07 (d, J=8.6 Hz, 1H), 7.87-7.84 (m, 2H), 3.31 (s, 3H) ppm.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 2 h
  3. filtrationthe resulting solids were collected by filtration under reduced pressure

Sources & evidence

ORD record
ord-b71b00959e8e4ddd828033f370bb0fcf
Source dataset
uspto-grants-2014_11
Patent number
US08889683B2

Reaction notes

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