HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 86690166, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | PyBOP | HCID 2724699 | — |
| Reactant | 6-Ethylpyrimidin-4-ol | HCID 135407688 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86690166 | HCID 86690166 | 57.9% |
Reaction Steps
4 mL DIPEA and 3 g PYBOP was added to 2.9 g 6-ethyl-3H-pyrimidin-4-one in 10 mL DMF. The reaction was stirred 5 min at ambient temperature and 1.1 g piperazine-1-carboxylic acid tert-butyl ester was added. The reaction was stirred overnight at RT. The solvent was removed and the residue was purified by HPLC to give 1 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-b5208945adbd40a7b9be0d39b681567e |
| Source note | uspto-grants-2014_11 |