HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N'-(4-bromo-3-methyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | 4-Bromo-3-methylbenzoyl chloride | HCID 7021534 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N'-(4-bromo-3-methyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester | HCID 86690170 | 92.4% |
Reaction Steps
54.3 g 4-bromo-3-methyl-benzoyl chloride was added to 23.3 g triethylamine and 30.4 g hydrazinecarboxylic acid tert-butyl ester in 1 L dichlormethane. The reaction was stirred 1 h at RT and extracted with water. The organic layer was evaporated and the residue was crystallized with diisopropylether to give 70 g desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-eb0aaaf6f5234b76866f8d8fb0c4cd9b |
| Source note | uspto-grants-2014_11 |