HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester | HCID 86686516 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid | HCID 86686517 | 98.3% |
Reaction Steps
30.8 g of (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester was dissolved in 250 mL dioxane and a solution of 2.4 g LiOH in 250 mL of water was added. The mixture was stirred for 24 h at RT. The mixture was acidified with HCl-solution. The precipitate was filtered to give 29 g of the desired product. Rt: 1.28 min (method B), (M+H)+: 316
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-072bce86900d4ce697241386636acf68 |
| Source note | uspto-grants-2014_11 |