HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(2-(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride | HCID 86686520 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 86686522 | 66.9% |
Reaction Steps
1.8 g piperazine-1-carboxylic acid tert-butyl ester was added to 3.2 g (3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride and 1 g triethylamine in 50 mL dichlormethane. The reaction was stirred 1 day at RT, evaporated and purified by chromatography on silica gel (petrolether/diethylether:1/1) to yield 3.1 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-a868eac91f60404a8b525ed26e2e041a |
| Source note | uspto-grants-2014_11 |