反应详情

3.1 g 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazine-1-carboxylic acid tert-butyl ester was dissolved in 20 ml dichlormethane and 20 mL trifluor acetic acid was added. The reaction was stirred 24 h at RT and the solvent was evaporated. 10% potassiumcarbonate solution was added to the residue. The precipate was filtered and crystallized with a mixture of acetonitrile and isopropylether to give 2.3 g of the desired compound. (M+H)+: 384

1. customthe solvent was evaporated
2. addition10% potassiumcarbonate solution was added to the residue
3. filtrationThe precipate was filtered
4. customcrystallized with a mixture of acetonitrile and isopropylether