Dimethylamine → 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-dimethylamino-pyrimidin-4-yl)-piperazin-1-yl)-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Dimethylamine	HCID 674	—
Reactant	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690173	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-dimethylamino-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690172	—

Reaction Steps

40 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 2 mL 2 M dimethylamine solution in THF were stirred 30 min at 170° C. under microwave condition. The mixture was purified by HPLC to give 19.1 mg of the desired product. Rt: 1.88 min (method I), (M+H)+: 505

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08889677B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-bf540b1872f64a04883bbbb81a3bf238
Source note	uspto-grants-2014_11