Methyl iodide → HCID 59186228, compound

Participants

Reaction Steps

To the solution of (4-(5-(3-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)methanol (200 mg, 0.51 mmol) in dimethyl sulfoxide (2 mL) was sequentially added potassium hydroxide (28 mg, 0.51 mmol) and iodomethane. After 3 hr, the reaction mixture was partitioned between water and dichloromethane. The collected organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. Purification by preparative thin layer chromatography afforded the desired product (45 mg, 12%). LCMS (ESI) m/z: 409.0.

Provenance & Evidence