Methyl pyruvate → HCID 72321878, compound

HRID 336443Notes

Reaction equation

HRID 336443 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1.[C:14]([O:19][CH3:20])(=[O:18])[C:15]([CH3:17])=O.C([O-])(=O)C.[Na+]>CO>[CH3:20][O:19][C:14](=[O:18])[C:15](=[N:10][NH:9][C:6]1[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][C:5]=1[N+:11]([O-:13])=[O:12])[CH3:17]

Participants

5

Reactant 3

HCID 11748Methyl pyruvateHCID 517045Sodium AcetateHCID 21901091HCID 21901091, compound

Product 1

HCID 72321878HCID 72321878, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(4-Chloro-2-nitro-phenyl)hydrazine hydrochloride (30 g, 0.14 mol) prepared in Step A and methyl pyruvate (14.4 mL, 0.16 mol) were dissolved in methanol (300 mL), and sodium acetate (14.2 g, 0.17 mol) was added thereto. The reaction solution was stirred for 8 h at room temperature, and the resulting yellow solid was filtered, washed with water and methanol, and dried to give the title compound (30 g, Yield 82%).

Workup

  1. filtrationthe resulting yellow solid was filtered
  2. washwashed with water and methanol
  3. customdried

Sources & evidence

ORD record
ord-b51b517fca5541fe80d243a8f7242fd6
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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