Methyl 3-chloro-2-oxopropanoate → 2-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

HRID 336475Notes

Reaction equation

HRID 336475 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4](=O)[CH2:5]Cl.[N+:9]([C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:20]=1[NH:19][C:18]([C:21](=[S:23])[NH2:22])=[CH:17]2)([O-:11])=[O:10]>>[CH3:1][O:2][C:3]([C:4]1[N:22]=[C:21]([C:18]2[NH:19][C:20]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N+:9]([O-:11])=[O:10])[S:23][CH:5]=1)=[O:8]

Participants

3

Reactant 2

HCID 12530121Methyl 3-chloro-2-oxopropanoateHCID 579018667-nitro-1H-indole-2-carbothioamide

Product 1

HCID 1363372002-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

Procedure

3-Chloro-2-oxo-propionic acid methyl ester and 7-nitro-1H-indole-2-carbothioic acid amide prepared in Step A of Preparation 110 were reacted according to the same procedure as Preparation 110 to give the title compound.

Workup

  1. customwere reacted
  2. customaccording to the same procedure as Preparation 110

Sources & evidence

ORD record
ord-22f1d1ba325d4d3a99248aca1a9a4d43
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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