7-nitro-1H-indole-2-carboxylic acid → 3-(Hydroxyimino)-3-[(7-nitro-1H-indole-2-carbonyl)-amino]-propionic acid methyl ester

HRID 336477Notes

Reaction equation

HRID 336477 reaction equation
[CH3:1][O:2][C:3](=[O:9])[CH2:4][C:5](=[NH:8])[NH:6][OH:7].[N+:10]([C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:21]=1[NH:20][C:19]([C:22](O)=[O:23])=[CH:18]2)([O-:12])=[O:11]>>[CH3:1][O:2][C:3](=[O:9])[CH2:4][C:5](=[N:6][OH:7])[NH:8][C:22]([C:19]1[NH:20][C:21]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][C:13]=2[N+:10]([O-:12])=[O:11])=[O:23]

Participants

3

Reactant 2

HCID 814097-nitro-1H-indole-2-carboxylic acidHCID 178500867HCID 178500867, compound

Product 1

HCID 1363372013-(Hydroxyimino)-3-[(7-nitro-1H-indole-2-carbonyl)-amino]-propionic acid methyl ester

Procedure

2-(N-hydroxycarbamimidoyl)-acetic acid methyl ester prepared in Step A and 7-nitro-1H-indole-2-carboxylic acid prepared in Step A of Preparation 101 were reacted according to the same procedure as Step B of Preparation 101 to give the title compound.

Workup

  1. customwere reacted
  2. customaccording to the same procedure as Step B of Preparation 101

Sources & evidence

ORD record
ord-998da11242154bf3b0adb1220713bd78
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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