Cyclopentanone → HCID 86644361, compound

HRID 336483Notes

Reaction equation

HRID 336483 reaction equation
[CH3:1][C:2]([CH3:33])([CH3:32])[C:3]([O:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[C:14]([N+:16]([O-])=O)[CH:15]=1)[NH:12][C:11]([C:19]1[S:20][CH2:21][C@@H:22]([CH2:24][O:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28])[N:23]=1)=[CH:10]2)=[O:4].[C:34]1(=O)[CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH:34]1([NH:16][C:14]2[CH:15]=[C:7]([CH2:6][O:5][C:3](=[O:4])[C:2]([CH3:33])([CH3:32])[CH3:1])[CH:8]=[C:9]3[C:13]=2[NH:12][C:11]([C:19]2[S:20][CH2:21][C@@H:22]([CH2:24][O:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28])[N:23]=2)=[CH:10]3)[CH2:38][CH2:37][CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 8452CyclopentanoneHCID 59543096HCID 59543096, compound

Product 1

HCID 86644361HCID 86644361, compound

Procedure

2,2-Dimethyl-propionic acid (R)-2-[5-(2,2-dimethyl-propionyloxymethyl)-7-nitro-1H-indol-2-yl]-4,5-dihydro-thiazol-4-yl-methyl ester prepared in Preparation 43 and cyclopentanone were reacted according to the same procedure as Example 1 to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a464bd2e146e43e7b4cfdfd72aecf8c9
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

Loading…