1,4-Dioxaspiro[4.5]decan-8-one → HCID 68486748, compound

HRID 336485Notes

Reaction equation

HRID 336485 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C@@H:6]1[CH2:10][S:9][C:8]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=3[N+:21]([O-])=O)=[N:7]1)[CH3:2].[O:25]1[C:29]2([CH2:34][CH2:33][C:32](=O)[CH2:31][CH2:30]2)[O:28][CH2:27][CH2:26]1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C@@H:6]1[CH2:10][S:9][C:8]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=3[NH:21][CH:32]2[CH2:33][CH2:34][C:29]3([O:28][CH2:27][CH2:26][O:25]3)[CH2:30][CH2:31]2)=[N:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 68486047HCID 68486047, compound

Product 1

HCID 68486748HCID 68486748, compound

Procedure

[(R)-2-(5-methyl-7-nitro-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-acetic acid ethyl ester prepared in Preparation 54 and 1,4-dioxa-spiro[4,5]decan-8-one were reacted according to the same procedure as Example 1 to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-79d891064d264a0b9add2d6874ef377e
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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