2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanol → 3-{2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethyl}-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester

HRID 336500Notes

Reaction equation

HRID 336500 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23]O)[N:21]=1)=[CH:5]2.[CH2:25]([O:27][C:28]([C:30]1[NH:31][CH:32]=[N:33][C:34]=1[CH3:35])=[O:29])[CH3:26]>>[CH2:25]([O:27][C:28]([C:30]1[N:31]([CH2:23][CH2:22][C@@H:20]2[CH2:19][S:18][C:17]([C:6]3[NH:7][C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([Cl:1])=[CH:10][C:9]=4[NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)=[N:21]2)[CH:32]=[N:33][C:34]=1[CH3:35])=[O:29])[CH3:26]

Participants

3

Reactant 2

HCID 251961462-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanolHCID 178470400HCID 178470400, compound

Product 1

HCID 595430933-{2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethyl}-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Procedure

2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanol prepared in Example 5 and 5-methyl-3H-imidazole-4-carboxylic acid ethyl ester were reacted according to the same procedure as Example 156 to give the title compound.

Sources & evidence

ORD record
ord-299e182584604791848d0f34fd1269cc
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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