Sodium Methoxide → HCID 59543042, compound

HRID 336503Notes

Reaction equation

HRID 336503 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][CH:19]([CH2:21][CH2:22][OH:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:24][O-].[Na+]>>[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][CH2:22][O:23][CH3:24])[N:20]=2)=[CH:12]3)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 66974439HCID 66974439, compound

Product 1

HCID 59543042HCID 59543042, compound

Procedure

2-[2-(7-Cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanol prepared in Example 77 and sodium methoxide were reacted according to the same procedure as Example 165 to give the title compound.

Sources & evidence

ORD record
ord-f49413a0dcbc4a8499ae343f2672cb37
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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