Morpholine → HCID 68478808, compound

HRID 336505Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH2:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[CH:10]=1)[NH:7][C:6]([C:19]1[S:20][CH2:21][C@@H:22]([CH2:24][CH2:25]O)[N:23]=1)=[CH:5]2.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH2:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[CH:10]=1)[NH:7][C:6]([C:19]1[S:20][CH2:21][C@H:22]([CH2:24][CH2:25][N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[N:23]=1)=[CH:5]2

Participants

Reactant 2

HCID 8083Morpholine

HCID 68486023HCID 68486023, compound

Product 1

HCID 68478808HCID 68478808, compound

Procedure

2-((R)-2-{5-methyl-7-[(tetrahydro-pyran-4-ylmethyl)-amino]-1H-indol-2-yl}-4,5-dihydro-thiazol-4-yl)-ethanol prepared in Step B and morpholine were reacted according to the same procedure as Example 156 to give the title compound.

Sources & evidence

ORD record: ord-86871643ccbc4a7a93c5f22871620a6f
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889691B2

Reaction notes

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