2-Furancarboxylic acid → HCID 68105886, compound

HRID 336507Notes

Reaction equation

HRID 336507 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([NH:12][CH:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[CH:11]=1)[NH:8][C:7]([C:18]1[S:19][CH2:20][C@@H:21]([CH2:23][OH:24])[N:22]=1)=[CH:6]2.[O:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30](O)=[O:31]>>[CH:13]1([NH:12][C:10]2[CH:11]=[C:3]([CH2:2][NH:1][C:30]([C:26]3[O:25][CH:29]=[CH:28][CH:27]=3)=[O:31])[CH:4]=[C:5]3[C:9]=2[NH:8][C:7]([C:18]2[S:19][CH2:20][C@@H:21]([CH2:23][OH:24])[N:22]=2)=[CH:6]3)[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 69192-Furancarboxylic acidHCID 68485833HCID 68485833, compound

Product 1

HCID 68105886HCID 68105886, compound

Procedure

[(R)-2-(5-aminomethyl-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-methanol prepared in Example 258 and furan-2-carboxylic acid were reacted according to the same procedure as Step B of Preparation 101 to give the title compound.

Workup

  1. customaccording to the same procedure as Step B of Preparation 101

Sources & evidence

ORD record
ord-9913867f511f44d59b5cb99685507025
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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