1-Acetoxy-2-bromoethane → HCID 68487074, compound

HRID 336508Notes

Reaction equation

HRID 336508 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][OH:22])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23]([O:26][CH2:27]CBr)(=[O:25])[CH3:24]>>[CH3:27][O:26][C:23](=[O:25])[CH2:24][O:22][CH2:21][C@@H:19]1[CH2:18][S:17][C:16]([C:13]2[NH:14][C:15]3[C:11]([CH:12]=2)=[CH:10][CH:9]=[CH:8][C:7]=3[NH:6][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[N:20]1

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 25196143HCID 25196143, compound

Product 1

HCID 68487074HCID 68487074, compound

Procedure

[(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-1,3-thiazol-4-yl]-methanol prepared in Example 2 and bromoethyl acetate were reacted according to the same procedure as Step B of Preparation 29 to give the title compound.

Workup

  1. customaccording to the same procedure as Step B of Preparation 29

Sources & evidence

ORD record
ord-b73ee914fbaa491ea94757c8cf98e19f
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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