Benzyl Alcohol → HCID 70653970, compound

Participants

Reaction Steps

In an argon atmosphere, 2,6-dichloroisonicotinic acid (57.6 g) was gradually added to 55% sodium hydride (52.5 g) and dimethylformamide (1 L) while being cooled and stirred. Subsequently, benzyl alcohol (93 mL) was gradually added dropwise to the reaction product at the same temperature. After hydrogen was no longer generated, the reaction product was stirred for 4 hours at 80° C., and water (1 L) was then added thereto. The mixture was separated by a mixed solvent (1 L) of ethyl acetate and n-hexane (1:1). The acidity of the aqueous layer was lowered with acetic acid (75.5 mL), and water (1.7 L) was further added thereto. The precipitate was filtered and dried to obtain Compound 2a.

Provenance & Evidence