4-Chloroaniline → HCID 53252615, compound

HRID 336519Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[C:23](=[O:24])[N:22]([CH3:25])[C:14]3[N:15]=[C:16](S(C)=O)[N:17]=[CH:18][C:13]=3[CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][CH:31]=[CH:30]2.Cl[C:37]1C=CC(N)=CC=1>>[NH:32]1[C:33]2[C:29](=[CH:28][C:27]([NH:26][C:16]3[N:17]=[CH:18][C:13]4[CH:12]=[C:11]([S:8]([C:5]5[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=5)(=[O:10])=[O:9])[C:23](=[O:24])[N:22]([CH2:25][CH3:37])[C:14]=4[N:15]=3)=[CH:35][CH:34]=2)[CH:30]=[CH:31]1

Participants

Reactant 3

HCID 78124-Chloroaniline

HCID 788675-Aminoindole

HCID 67236377HCID 67236377, compound

Product 1

HCID 53252615HCID 53252615, compound

Procedure

The title compound was prepared according to the procedure of Example 3, substituting 8-ethyl-2-(methylsulfinyl)-6-(phenylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one for 6-(4-chlorophenylsulfonyl)-8-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one, and 5-aminoindole for 4-chloroaniline.

Sources & evidence

ORD record: ord-d2683c2d2a2d445882f709516fde40b1
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889696B2

Reaction notes

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