Diisopropylethylamine → HCID 68000648, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 1 (step 1.3.). Starting with 0.45 g (1.04 mmol) of ethyl 5-(6-azaspiro[3.4]oct-2-ylcarbamoyloxymethyl)isoxazole-3-carboxylate trifluoroacetate, described in step 6.6., 0.198 g (1.04 mmol) of 2-fluoro-5-(4-fluorophenyl)pyridine, prepared in step 6.7. and 0.40 g (3.12 mmol) of N,N-diisopropylethylamine, and after purification by chromatography on preparative plates, eluting with a 96/4 mixture of dichloromethane and methanol, 0.10 g of pure product is obtained in the form of a wax, which is used without further purification in the following step.

Provenance & Evidence