HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate | HCID 56962170 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate | HCID 68001449 | — |
Reaction Steps
Raney nickel is added in catalytic amount to a solution of 0.27 g (1.14 mmol) of tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate (isomer 1a), obtained in step 8.1., in 10 mL of a 1N solution of sodium hydroxide in ethanol. The reaction medium is placed in a Parr flask under a hydrogen atmosphere (4 bar), at room temperature for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889702B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-feb8fcb3084044cd90bcdf9089cc41ec |
| Source note | uspto-grants-2014_11 |