Tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate → tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate

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Reaction Steps

The process is performed according to the procedure described in Example 8 (step 8.2.). Starting with 0.20 g (0.85 mmol) of ter-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate, (isomer 1b), described in Example 8 (step 8.1.) and a catalytic amount of Raney nickel, 0.22 g of product is obtained in the form of a yellow oil, which is used without further purification in the following step.

Provenance & Evidence