Tetrahydrofuran → 7-[5-(4-Fluorophenyl)pyridin-2-yl]-7-azaspiro[3.5]nonan-2-ol

Participants

Reaction Steps

The process is performed according to the procedure described in Example 2 (step 2.7.). Starting with 0.138 g (0.46 mmol) of 7-(5-bromopyridin-2-yl)-7-azaspiro[3.5]nonan-2-ol, obtained in step 10.1., 0.078 g (0.56 mmol) of 4-fluorophenylboronic acid, 0.454 g (1.39 mmol) of caesium carbonate suspended in 3 mL of a 9/1 mixture of tetrahydrofuran and water. 0.038 g (0.05 mmol) of PdCl2dppf.CH2Cl2 is then added. 0.101 g of pure product is thus obtained in the form of a grey powder.

Provenance & Evidence