反应详情

The process is performed according to the procedure described in Example 6, step 6.1. Starting with 1.40 g (6.63 mmol) of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate, obtained in step 11.2., dissolved in 17 mL of methanol and 0.376 g (9.94 mmol) of sodium borohydride. After evaporating off the solvent and crystallizing from a 70/30 mixture of petroleum ether and diisopropyl ether, 1.18 g of the expected product are obtained in the form of a white powder.

1. customobtained in step 11.2
2. customAfter evaporating off the solvent
3. customcrystallizing from a 70/30 mixture of petroleum ether and diisopropyl ether, 1.18 g of the expected product
4. customare obtained in the form of a white powder