Sodium Azide → tert-Butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate
Reaction equation
CS(O[CH:6]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]2)[CH2:7]1)(=O)=O.[N-:21]=[N+:22]=[N-:23].[Na+]>>[N:21]([CH:6]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]2)[CH2:7]1)=[N+:22]=[N-:23]Participants
3
Procedure
The process is performed according to the procedure described in Example 6 (step 6.3.). Starting with 1.62 g (5.30 mmol) of tert-butyl 2-methanesulfonyloxy-6-azaspiro[3.4]octane-6-carboxylate (isomer 1′), described in Example 12 (step 12.1.), and 0.68 g (10.61 mmol) of sodium azide, the product is obtained in the form of a yellow oil, which is used without further purification in the following step.
Workup
- customthe product is obtained in the form of a yellow oil, which
- customis used without further purification in the following step
Sources & evidence
- ORD record
- ord-63fa4deeb32842f681dceedd4ced6b42
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08889702B2
Reaction notes
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