5-Bromo-2-fluoropyridine → HCID 68000491, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 2 (step 2.6.). Starting with 0.43 g (1.03 mmol) of ethyl 5-(6-azaspiro[3.4]oct-2-ylcarbamoyloxymethyl)isoxazole-3-carboxylate trifluoroacetate (isomer 5′), obtained in step 12.5., and 0.45 g (2.60 mmol) of 2-fluoro-5-bromopyridine, and after chromatography on silica gel, eluting with a 97/3 mixture of dichloromethane and methanol, 0.68 g of pure product is obtained in the form of an oil.

Provenance & Evidence